DAP
Function
Ribosome-binding protein involved in ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with eiF5a (EIF5A and EIF5A2) at the polypeptide exit tunnel of the ribosome, preventing mRNA translation (By similarity). Involved in ribosome hibernation in the mature oocyte by preventing mRNA translation, leading to ribosome inactivation (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also acts as a negative regulator of autophagy (PubMed:20537536). Involved in mediating interferon-gamma-induced cell death (PubMed:7828849).
Post-translational modifications
Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy.
Sequence Similarities
Belongs to the DAP-DAPL1 family.
Alternative names
DAP1, DAP, Death-associated protein 1, DAP-1