DAPP1
Function
May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K.
Post-translational modifications
Phosphorylated on tyrosine residues.
Tissue Specificity
Highly expressed in placenta and lung, followed by brain, heart, kidney, liver, pancreas and skeletal muscle. Expressed by B-lymphocytes, but not T-lymphocytes or nonhematopoietic cells.
Cellular localization
- Cytoplasm
- Membrane
- Peripheral membrane protein
- Membrane-associated after cell stimulation leading to its translocation.
Alternative names
BAM32, HSPC066, DAPP1, Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide, hDAPP1, B lymphocyte adapter protein Bam32, B-cell adapter molecule of 32 kDa