DAZL

Developmental stage

In the testis, expression increases steadily after birth until the first spermatogonial cells appear, levels off as the first spermatogenic cells enter meiosis (10 days after birth) and remains at this level thereafter.

Domain

The DAZ domain mediates the interaction with DAZAP1 and DAZAP2.

Function

RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts.

Sequence similarities

Belongs to the RRM DAZ family.

Tissue specificity

Expressed predominantly in testis with lower levels in ovary. In testis, it is expressed in pachytene spermatocytes and at lower level in type-B spermatogonia, preleptotene and zygotene spermatocytes. In ovary, it is expressed in maturing follicles. In embryonic and prepuberal ovary, it is expressed in the oocyte and follicular cells.

Cellular localization

• Cytoplasm

Alternative names

• Deleted in azoospermia-like
• DAZ-like autosomal
• Deleted in azoospermia-like 1
• Dazl
• Dazl1
• Dazla

Database links

• entrezGene:13164
• swissprot:Q64368

Target type

Proteins

Primary research area

Epigenetics

Molecular weight

33313Da