DAZL
Domain
The DAZ domain mediates the interaction with DAZAP1 and DAZAP2.
Function
RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity).
Sequence Similarities
Belongs to the RRM DAZ family.
Tissue Specificity
Testis specific.
Cellular localization
- Cytoplasm
- Nucleus
- Predominantly cytoplasmic. Nuclear in spermatogonia until near the end of the meiotic prophase and cytoplasmic localization from then onward.
Alternative names
DAZH, DAZL1, DAZLA, SPGYLA, DAZL, Deleted in azoospermia-like, DAZ homolog, DAZ-like autosomal, Deleted in azoospermia-like 1, SPGY-like-autosomal