DBF4

Function

Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.

Post-translational modifications

Phosphorylation increases its interaction with PSIP1.

Tissue Specificity

Highly expressed in testis and thymus. Expressed also in most cancer cells lines.

Cellular localization

• Nucleus

Alternative names

ASK, DBF4A, ZDBF1, DBF4, Protein DBF4 homolog A, Activator of S phase kinase, Chiffon homolog A, DBF4-type zinc finger-containing protein 1

Database links

swissprot:Q9UBU7 entrezGene:8317 entrezGene:10926 swissprot:O00311 omim:604281 omim:603311