DBF4B
Developmental stage
Increases as cells enter in S phase through G2/M phase. The protein has a short half-life (at protein level).
Function
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle.
Post-translational modifications
Phosphorylated.
Tissue Specificity
Widely expressed. Highly expressed in testis.
Cellular localization
- Nucleus
- Predominantly found in soluble fraction but not in the chromatin-bound fraction.
Alternative names
ASKL1, DRF1, DBF4B, Protein DBF4 homolog B, Activator of S phase kinase-like protein 1, Chiffon homolog B, Dbf4-related factor 1, ASK-like protein 1