Dbh
Function
Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters.
Pathway
Catecholamine biosynthesis; (R)-noradrenaline biosynthesis; (R)-noradrenaline from dopamine: step 1/1.
Post-translational modifications
Proteolytic cleavage after the membrane-anchor leads to the release of the soluble form.
N-glycosylated.
Sequence Similarities
Belongs to the copper type II ascorbate-dependent monooxygenase family.
Tissue Specificity
Chromaffin granules of the adrenal medulla and synaptic vesicles of the sympathetic nervous system.
Cellular localization
- Soluble dopamine beta-hydroxylase
- Cytoplasmic vesicle
- Secretory vesicle lumen
- Cytoplasmic vesicle
- Secretory vesicle
- Chromaffin granule lumen
- Secreted
- Cytoplasmic vesicle
- Secretory vesicle membrane
- Single-pass type II membrane protein
- Cytoplasmic vesicle
- Secretory vesicle
- Chromaffin granule membrane
- Single-pass type II membrane protein
Alternative names
Dopamine beta-hydroxylase, Dopamine beta-monooxygenase