Acyl-CoA-binding protein

Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.

Belongs to the ACBP family.

Isoform 1 is ubiquitous, with a moderate expression level. Isoform 2 is ubiquitous with high level in liver and adipose tissue. Isoform 3 is ubiquitous with strong expression in adipose tissue and heart.

• Endoplasmic reticulum
• Golgi apparatus
• Golgi localization is dependent on ligand binding (PubMed:17953517).

Acyl-CoA-binding protein, ACBP, Diazepam-binding inhibitor, Endozepine, DBI, EP

• entrezGene:1622
• omim:125950
• swissprot:P07108

Proteins

Metabolism

11793Da