DCAF5
Function
Is a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex (CRL4) (PubMed:29691401, PubMed:30442713). The complex CRL4-DCAF5 is involved in the ubiquitination of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1 (PubMed:29691401, PubMed:30442713).
Pathway
Protein modification; protein ubiquitination.
Tissue Specificity
Ubiquitous.
Alternative names
BCRG2, KIAA1824, WDR22, DCAF5, DDB1- and CUL4-associated factor 5, Breakpoint cluster region protein 2, WD repeat-containing protein 22, BCRP2