DCAF6
Function
Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Pathway
Protein modification; protein ubiquitination.
Tissue Specificity
Highly expressed in skeletal muscle and testis. Expressed to a lesser degree in heart, prostate, and adrenal gland.
Cellular localization
- Nucleus
Alternative names
IQWD1, MSTP055, DCAF6, DDB1- and CUL4-associated factor 6, Androgen receptor complex-associated protein, IQ motif and WD repeat-containing protein 1, Nuclear receptor interaction protein, ARCAP, NRIP