DCAF7
Function
Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Pathway
Protein modification; protein ubiquitination.
Sequence Similarities
Belongs to the WD repeat DCAF7 family.
Cellular localization
- Cytoplasm
- Nucleus
- Overexpression of DIAHP1 or active RHOA causes translocation from the nucleus to cytoplasm.
Alternative names
HAN11, WDR68, DCAF7, DDB1- and CUL4-associated factor 7, WD repeat-containing protein 68, WD repeat-containing protein An11 homolog