DCK
Function
Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine (PubMed:12808445, PubMed:18377927, PubMed:19159229, PubMed:1996353, PubMed:20614893, PubMed:20637175). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents (PubMed:12808445).
Post-translational modifications
Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK1.
Sequence Similarities
Belongs to the DCK/DGK family.
Cellular localization
- Nucleus
Alternative names
Deoxycytidine kinase, dCK, Deoxyadenosine kinase, Deoxyguanosine kinase, DCK