DCLK2
Developmental stage
Expressed in fetal brain, and, to a lower extent, in fetal kidney.
Domain
The doublecortin domains are involved in the colocalization with microtubules.
Function
Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity).
Post-translational modifications
Autophosphorylated.
Sequence Similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Tissue Specificity
Expressed in the brain, heart and eyes.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Colocalizes with microtubules.
Alternative names
DCAMKL2, DCDC3B, DCK2, DCLK2, Serine/threonine-protein kinase DCLK2, CaMK-like CREB regulatory kinase 2, Doublecortin domain-containing protein 3B, Doublecortin-like and CAM kinase-like 2, Doublecortin-like kinase 2, CL2, CLICK-II, CLICK2