DCLRE1A
Function
May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (PubMed:31434986). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (PubMed:31434986).
Sequence Similarities
Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
Tissue Specificity
Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle.
Cellular localization
- Nucleus
- In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1. Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross-linking agents. These foci overlap with those formed by the MRN complex (composed of MRE11, RAD50 and NBN) and BRCA1.
Alternative names
KIAA0086, SNM1, SNM1A, DCLRE1A, DNA cross-link repair 1A protein, Beta-lactamase DCLRE1A, SNM1 homolog A, hSNM1, hSNM1A