DCN
Function
May affect the rate of fibrils formation.
Involvement in disease
Corneal dystrophy, congenital stromal
CSCD
A corneal dystrophy characterized by congenital corneal opacification consisting of a large number of flakes and spots throughout all layers of the stroma. It results in progressive, painless visual loss. Corneal erosions and photophobia are absent.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.
Sequence Similarities
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
Tissue Specificity
Detected in placenta (at protein level) (PubMed:32337544). Detected in cerebrospinal fluid, fibroblasts and urine (at protein level) (PubMed:25326458, PubMed:36213313, PubMed:37453717).
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
- Secreted
Alternative names
SLRR1B, DCN, Decorin, Bone proteoglycan II, PG-S2, PG40