DCP1A
Function
Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:12417715). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12417715). Contributes to the transactivation of target genes after stimulation by TGFB1 (PubMed:11836524). Essential for embryonic development (PubMed:33813271).
Sequence Similarities
Belongs to the DCP1 family.
Tissue Specificity
Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas.
Cellular localization
- Cytoplasm
- P-body
- Nucleus
- Co-localizes with NANOS3 in the processing bodies (By similarity). Predominantly cytoplasmic, in processing bodies (PB) (PubMed:16364915). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4 (PubMed:11836524).
Alternative names
SMIF, DCP1A, mRNA-decapping enzyme 1A, Smad4-interacting transcriptional co-activator, Transcription factor SMIF