Dct
Function
Plays a role in melanin biosynthesis (PubMed:33100333). Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA) (PubMed:1537333, PubMed:1537334).
Involvement in disease
The slaty mutation in Tyrp2 leads to a decrease of DT activity and a consequent change in the pigmentation of the mice to a dark gray/brown eumelanin. The slaty-2j mutation has a similar phenotype, the slaty-lt (light) mutation has a more severe effect and is semidominant; its phenotype may be a result of the failure of the enzyme to be correctly targeted to its normal location on the inner face of the melanosomal membrane.
Pathway
Pigment biosynthesis; melanin biosynthesis.
Post-translational modifications
Glycosylated.
Sequence Similarities
Belongs to the tyrosinase family.
Tissue Specificity
Melanocytes and retinal pigmented epithelium (at protein level).
Cellular localization
- Melanosome membrane
- Single-pass type I membrane protein
- Melanosome
- Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38.
Alternative names
Tyrp-2, Tyrp2, Dct, L-dopachrome tautomerase, DCT, DT, DOPAchrome conversion factor, DOPAchrome isomerase, DOPAchrome oxidoreductase, L-dopachrome Delta-isomerase, SLATY locus protein, Tyrosinase-related protein 2, TRP-2, TRP2