DCT

Function

Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA).

Pathway

Pigment biosynthesis; melanin biosynthesis.

Post-translational modifications

Glycosylated.

Sequence similarities

Belongs to the tyrosinase family.

Cellular localization

• Melanosome membrane
• Single-pass type I membrane protein
• Melanosome
• Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38.

Alternative names

• L-dopachrome tautomerase
• DCT
• DT
• L-dopachrome Delta-isomerase
• Tyrosinase-related protein 2
• TRP-2
• TRP2
• TYRP2
• DCT

Database links

• entrezGene:1638
• omim:191275
• swissprot:P40126

Target type

Proteins

Molecular weight

59145Da