DCTN3

Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Together with dynein may be involved in spindle assembly and cytokinesis (PubMed:9722614).

Belongs to the dynactin subunit 3 family.

Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels in brain.

• Cytoplasm
• Cytoplasm
• Cytoskeleton
• Microtubule organizing center
• Centrosome
• Chromosome
• Centromere
• Kinetochore
• Cytoplasm
• Cytoskeleton
• Spindle
• Cleavage furrow
• Midbody
• Localizes to punctate cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles throughout mitosis. Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells.

DCTN22, DCTN3, Dynactin subunit 3, Dynactin complex subunit 22 kDa subunit, p22

• entrezGene:11258
• omim:607387
• swissprot:O75935

Proteins

Neuroscience

21119Da