DCTN3

Function

Together with dynein may be involved in spindle assembly and cytokinesis.

Sequence similarities

Belongs to the dynactin subunit 3 family.

Tissue specificity

Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels in brain.

Cellular localization

• Cytoplasm
• Cytoplasm
• Cytoskeleton
• Microtubule organizing center
• Centrosome
• Chromosome
• Centromere
• Kinetochore
• Cytoplasm
• Cytoskeleton
• Spindle
• Cleavage furrow
• Midbody
• Localizes to punctate cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles throughout mitosis. Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells.

Alternative names

• Dynactin subunit 3
• Dynactin complex subunit 22 kDa subunit
• p22
• DCTN3
• DCTN22

Database links

• entrezGene:11258
• omim:607387
• swissprot:O75935

Target type

Proteins

Molecular weight

21119Da