DCUN1D2
Domain
The DCUN1 domain, also known as PONY domain, mediates the interaction with different cullins (PubMed:23201271). The DCUN1 domain mediates the interaction with the N-terminally acetylated NEDD8-conjugating E2s enzyme leading to the NEDD8 transfer from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes; the neddylation efficiency correlates with the DCUN1D5-cullin and DCUN1D5-E2 interaction affinities (PubMed:23201271).
Function
Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and plays an essential role in the regulation of SCF (SKP1-CUL1-F-box protein)-type complexes activity.
Tissue Specificity
Mostly expressed in liver, kidney and brain.
Cellular localization
- Cytoplasm
- Nucleus
Alternative names
C13orf17, DCUN1L2, DCUN1D2, DCN1-like protein 2, DCNL2, DCUN1 domain-containing protein 2, Defective in cullin neddylation protein 1-like protein 2