Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
Pentosuria
PNTSU
An inborn error of metabolism characterized by excessive urinary excretion of L-xylulose.
None
The disease is caused by variants affecting the gene represented in this entry.
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Highly expressed in kidney, liver and epididymis. In the epididymis, it is mainly expressed in the proximal and distal sections of the corpus region. Weakly or not expressed in brain, lung, heart, spleen and testis.
Proteins
25913Da
We found 7 products in 3 categories
ab110283
ab154290
ab191369