DDAH1
Function
Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.
Sequence Similarities
Belongs to the DDAH family.
Tissue Specificity
Detected in brain, liver, kidney and pancreas, and at low levels in skeletal muscle.
Alternative names
DDAH, DDAH1, DDAH-1, Dimethylarginine dimethylaminohydrolase 1, DDAHI, Dimethylargininase-1