Deaminated glutathione amidase
Function
Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells.
Sequence Similarities
Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.
Tissue Specificity
Detected in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.
Cellular localization
- Isoform 2
- Mitochondrion
- Isoform 1
- Cytoplasm
Alternative names
Deaminated glutathione amidase, dGSH amidase, Nitrilase homolog 1, NIT1