DEDD
Function
A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity).
Post-translational modifications
Exists predominantly in a mono- or diubiquitinated form.
Tissue Specificity
Widely expressed with highest levels in testis.
Cellular localization
- Cytoplasm
- Nucleus
- Nucleolus
- Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli (By similarity). Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells.
Alternative names
DEDPRO1, DEFT, KE05, DEDD, Death effector domain-containing protein, DEDPro1, Death effector domain-containing testicular molecule, FLDED-1