DEFA3

Function

Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses (PubMed:15616305, PubMed:15772169, PubMed:17142766). Possesses the ability to neutralize bacterial toxins such as B. anthracis lethal factor, Clostridium difficile cytotoxin B as well as leukocidin produced by Staphylococcus aureus (PubMed:15772169, PubMed:18435932, PubMed:25963798). Blocks also herpes simplex virus infection by interacting with envelope glycoprotein B and thus preventing its binding to heparan sulfate, the receptor for attachment (PubMed:17142766).

Sequence Similarities

Belongs to the alpha-defensin family.

Cellular localization

• Secreted

Alternative names

DEF3, DEFA3, Neutrophil defensin 3, HNP-3, HP-3, HP3

Database links

swissprot:P59666 entrezGene:728358 omim:604522 entrezGene:1667 swissprot:P59665 entrezGene:1668