DEK
Function
Involved in chromatin organization.
Involvement in disease
A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia (PubMed:1549122). Translocation t(6;9)(p23;q34) with NUP214/CAN (PubMed:1549122). It results in the formation of a DEK-NUP214 fusion gene (PubMed:1549122).
Post-translational modifications
Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G(1) phase, and weakens the binding of DEK to DNA.
Tissue Specificity
Ubiquitous. Expressed at relatively high levels.
Cellular localization
- Nucleus
- Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei.
Alternative names
Protein DEK, DEK