DERA
Function
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation.
Pathway
Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.
Sequence Similarities
Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
Tissue Specificity
Mainly expressed in liver, lung and colon.
Cellular localization
- Cytoplasm
- Cytoplasmic granule
- Nucleus
- Recruited to stress granules but not to processing bodies upon arsenite or clotrimazole treatment or energy deprivation.
Alternative names
CGI-26, DERA, Deoxyribose-phosphate aldolase, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase