DERL2
Function
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins (PubMed:16186509, PubMed:16449189). May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908).
(Microbial infection) In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses.
Sequence Similarities
Belongs to the derlin family.
Tissue Specificity
Ubiquitous. Overexpressed in various hepatocarcinomas.
Cellular localization
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
Alternative names
DER2, FLANA, CGI-101, SBBI53, DERL2, Derlin-2, Degradation in endoplasmic reticulum protein 2, Der1-like protein 2, F-LAN-1, F-LANa, DERtrin-2