Dermatopontin
Function
Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).
Post-translational modifications
Sulfated on tyrosine residue(s).
Sequence Similarities
Belongs to the dermatopontin family.
Tissue Specificity
Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts.
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
Alternative names
Dermatopontin, Tyrosine-rich acidic matrix protein, TRAMP, DPT