DESI1
Function
Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity (By similarity). Desumoylates ZBTB46 (By similarity). Collaborates with UBQLN4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity towards synthetic substrates 4-methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside and S-depalmitoylation probe 5 (DPP-5) (PubMed:35427157).
Sequence Similarities
Belongs to the DeSI family.
Cellular localization
- Cytoplasm
- Nucleus
- Shuttles between the nucleus and the cytoplasm; exported from the nucleus in a XPO1/CRM1-dependent manner via its nuclear export signal motifs.
Alternative names
FAM152B, PPPDE2, DESI1, Desumoylating isopeptidase 1, DeSI-1, PPPDE peptidase domain-containing protein 2, Palmitoyl protein thioesterase DESI1, Polyubiquitinated substrate transporter, S-depalmitoylase DESI1, POST