DEUP1
Function
Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity).
Sequence Similarities
Belongs to the CEP63 family.
Cellular localization
- Cytoplasm
- Localizes to the deuterosome.
Alternative names
CCDC67, DEUP1, Deuterosome assembly protein 1, Coiled-coil domain-containing protein 67