DGKB
Function
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11719522). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol (By similarity). Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (By similarity).
Isoform 2
Does not associate with membranes but has a diacylglycerol kinase activity.
Pathway
Lipid metabolism; glycerolipid metabolism.
Sequence Similarities
Belongs to the eukaryotic diacylglycerol kinase family.
Tissue Specificity
Isoform 1
Specifically expressed in brain but also detected in uterus (PubMed:11719522). In adult brain, expressed in the amygdala, caudate nucleus, and hippocampus (PubMed:11719522).
Isoform 2
More ubiquitously expressed but at lower level compared to isoform 1.
Cellular localization
- Postsynaptic cell membrane
- Peripheral membrane protein
- Cell membrane
- Peripheral membrane protein
- Cytoplasm
- Translocation to the plasma membrane is induced by phorbol esters.
- Isoform 2
- Cytoplasm
Alternative names
DAGK2, KIAA0718, DGKB, Diacylglycerol kinase beta, DAG kinase beta, 90 kDa diacylglycerol kinase, Diglyceride kinase beta, DGK-beta