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Function

Membrane-bound diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:15544348, PubMed:19744926, PubMed:21477596, PubMed:22108654, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:15544348, PubMed:8626589). Also plays an important role in the biosynthesis of complex lipids (PubMed:8626589). Displays specificity for diacylglycerol substrates with an arachidonoyl acyl chain at the sn-2 position, with the highest activity toward 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol the main diacylglycerol intermediate within the phosphatidylinositol turnover cycle (PubMed:19744926, PubMed:22108654, PubMed:23274426). Can also phosphorylate diacylglycerol substrates with a linoleoyl acyl chain at the sn-2 position but much less efficiently (PubMed:22108654).

Involvement in disease

Nephrotic syndrome 7

NPHS7

A form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. NPHS7 is an autosomal recessive form characterized by onset of proteinuria usually in the first decade of life. The disorder is progressive, and some patients develop end-stage renal disease within several years. Renal biopsy typically shows membranoproliferative glomerulonephritis.

None

The disease is caused by variants affecting the gene represented in this entry.

Hemolytic uremic syndrome, atypical, 7

AHUS7

An atypical form of hemolytic uremic syndrome characterized by acute onset in the first year of life of microangiopathic hemolytic anemia, thrombocytopenia, and renal failure. After the acute episode, most patients develop chronic renal insufficiency. Unlike other genetic forms of aHUS, AHUS7 is not related to abnormal activation of the complement system.

None

Disease susceptibility is associated with variants affecting the gene represented in this entry.

Pathway

Lipid metabolism; glycerolipid metabolism.

Sequence similarities

Belongs to the eukaryotic diacylglycerol kinase family.

Tissue specificity

Expressed predominantly in testis. Expressed in endothelium, platelets and podocytes (at protein level).

Cellular localization

  • Membrane
  • Single-pass membrane protein
  • Cytoplasm

Alternative names

DAGK5, DGKE, Diacylglycerol kinase epsilon, DAG kinase epsilon, Diglyceride kinase epsilon, DGK-epsilon

Target type

Proteins

Molecular weight

63927Da

We found 5 products in 2 categories

Primary Antibodies

Target

Application

Reactive species

Proteins & Peptides

Target

Species of origin

Search our catalogue for 'DGKE' (5)

Products

ab128949

Anti-DGKE antibody [EPR7847]

Recombinant
RabMAb