Dhcr24
Function
Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis (PubMed:26114596). In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis (By similarity).
Pathway
Steroid biosynthesis; cholesterol biosynthesis.
Sequence Similarities
Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
Cellular localization
- Endoplasmic reticulum membrane
- Single-pass membrane protein
- Golgi apparatus membrane
- Single-pass membrane protein
Alternative names
Kiaa0018, Dhcr24, Delta(24)-sterol reductase, 24-dehydrocholesterol reductase, 3-beta-hydroxysterol Delta-24-reductase