Dhodh
Function
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.
Post-translational modifications
The uncleaved transit peptide is required for mitochondrial targeting and proper membrane integration.
Sequence Similarities
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
Cellular localization
- Mitochondrion inner membrane
- Single-pass membrane protein
Alternative names
DHOdehase, Dihydroorotate oxidase, Dhodh