DHRS3
Function
Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.
Sequence Similarities
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Tissue Specificity
Widely expressed with highest levels found in heart, placenta, lung, liver, kidney, pancreas, thyroid, testis, stomach, trachea and spinal cord. Lower levels found in skeletal muscle, intestine and lymph node. No expression detected in brain. In the retina, expressed in cone but not rod outer segments.
Cellular localization
- Membrane
- Multi-pass membrane protein
Alternative names
RDH17, SDR16C1, UNQ2424/PRO4983, DHRS3, Short-chain dehydrogenase/reductase 3, DD83.1, Retinal short-chain dehydrogenase/reductase 1, Retinol dehydrogenase 17, Short chain dehydrogenase/reductase family 16C member 1, retSDR1