DHX33
Function
Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing (By similarity) (PubMed:21930779, PubMed:23871209, PubMed:26100019). Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment (PubMed:21930779). In the cytoplasm, promotes elongation-competent 80S ribosome assembly at the late stage of mRNA translation initiation (PubMed:26100019). Senses cytosolic dsRNA mediating NLRP3 inflammasome formation in macrophages and type I interferon production in myeloid dendritic cells (PubMed:23871209). Required for NLRP3 activation induced by viral dsRNA and bacterial RNA (PubMed:23871209). In dendritic cells, required for induction of type I interferon production induced by cytoplasmic dsRNA via the activation of MAPK and NF-kappa-B signaling pathways (By similarity).
Post-translational modifications
Ubiquitinated, leading to its degradation by the proteasome. Deubiquitinated by USP36.
Sequence Similarities
Belongs to the DEAD box helicase family. DEAH subfamily.
Cellular localization
- Nucleus
- Nucleolus
- Nucleus
- Nucleoplasm
- Cytoplasm
- Nucleus
- Inflammasome
- Predominantly in the nucleolus. During mitosis, localizes with the nucleolar organizing regions (PubMed:21930779). Upon dsRNA-binding, localizes in the inflammasome (PubMed:23871209).
Alternative names
DDX33, DHX33, ATP-dependent RNA helicase DHX33, DEAH box protein 33