Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Function
As part of the pyruvate dehydrogenase complex, catalyzes the transfers of an acetyl group to a lipoic acid moiety. The pyruvate dehydrogenase complex, catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle.
Post-translational modifications
Delipoylated at Lys-131 and Lys-258 by SIRT4, delipoylation decreases the PHD complex activity.
Sequence Similarities
Belongs to the 2-oxoacid dehydrogenase family.
Cellular localization
- Mitochondrion matrix
Alternative names
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, Pyruvate dehydrogenase complex component E2, PDC-E2, PDCE2, Dlat