DISP1
Function
Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). Synergizes with SCUBE2 to cause an increase in SHH secretion (PubMed:22902404).
Sequence Similarities
Belongs to the dispatched family.
Cellular localization
- Membrane
- Multi-pass membrane protein
Alternative names
DISPA, DISP1, Protein dispatched homolog 1