Dkk1
Developmental stage
Expressed in the developing brain, cochlea and limb buds.
Domain
The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
Function
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:18524778). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (PubMed:26206087). Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning (PubMed:18505822).
Sequence Similarities
Belongs to the dickkopf family.
Cellular localization
- Secreted
Alternative names
Dickkopf-related protein 1, Dickkopf-1, Dkk-1, mDkk-1, Dkk1