DKK2
Domain
The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
Function
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Post-translational modifications
May be proteolytically processed by a furin-like protease.
Sequence Similarities
Belongs to the dickkopf family.
Tissue Specificity
Expressed in heart, brain, skeletal muscle and lung.
Cellular localization
- Secreted
Alternative names
UNQ682/PRO1316, DKK2, Dickkopf-related protein 2, Dickkopf-2, Dkk-2, hDkk-2