DKK3
Domain
The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
Function
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Post-translational modifications
N- and O-glycosylated.
Sequence Similarities
Belongs to the dickkopf family.
Tissue Specificity
Highest expression in heart, brain, and spinal cord.
Cellular localization
- Secreted
Alternative names
REIC, UNQ258/PRO295, DKK3, Dickkopf-related protein 3, Dickkopf-3, Dkk-3, hDkk-3