Dkk3

The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

N- and O-glycosylated.

Belongs to the dickkopf family.

Highest expression in heart, brain, and spinal cord.

• Secreted

REIC, UNQ258/PRO295, DKK3, Dickkopf-related protein 3, Dickkopf-3, Dkk-3, hDkk-3

• entrezGene:27122
• omim:605416
• swissprot:Q9UBP4

Proteins

Oncology

38390Da