DKKL1
Domain
Contains a N-terminal domain similar to that of the N-terminal section of DKK3.
Function
Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduce testosterone synthesis in Leydig cells. Is not essential either for development or fertility.
Post-translational modifications
N-glycosylated during spermatogenesis. Not N-glycosylated in mature sperm.
Tissue Specificity
More highly expressed in adult testis than in fetal testis. Exclusively expressed in the testis (at protein level). Intense expression in stages II, III and IV of spermatogenesis, whereas expression is lower in stage I.
Cellular localization
- Secreted
- Cytoplasmic vesicle
- Secretory vesicle
- Acrosome
- Localized specifically to the crescent shaped acrosome at the apex of the sperm head.
Alternative names
SGY1, UNQ735/PRO1429, DKKL1, Dickkopf-like protein 1, Cancer/testis antigen 34, Protein soggy-1, CT34, SGY-1