DLG2
Domain
An N-terminally truncated L27 domain is predicted in isoform 2 at positions 1 through 27.
Function
Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity).
Post-translational modifications
Palmitoylation of isoform 1 is not required for targeting to postsynaptic density.
Sequence Similarities
Belongs to the MAGUK family.
Cellular localization
- Cell membrane
- Lipid-anchor
- Postsynaptic density
- Synapse
- Membrane
- Cell projection
- Axon
- Perikaryon
- Concentrated in soma and postsynaptic density of a subset of neurons.
Alternative names
Disks large homolog 2, Channel-associated protein of synapse-110, Postsynaptic density protein PSD-93, Chapsyn-110, DLG2