Dlg2
Developmental stage
High levels in developing brain and spinal chord, sensory neurons of dorsal root and trigeminal ganglia, myenteric neurons of the intestine as well as in non-neuronal cells of adrenal, thymus and submandibular glands of 15 dpc embryos.
Function
Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity).
Post-translational modifications
Palmitoylation of isoform 1 and isoform 2 is not required for targeting to postsynaptic density.
Sequence Similarities
Belongs to the MAGUK family.
Tissue Specificity
Detected in juxtaparanodal zones in the central nervous system and at nerve terminal plexuses of basket cells in the cerebellum (at protein level) (PubMed:20089912). Brain. High levels in cerebellar Purkinje cells. Expressed in pyramidal cells of the Ammons's horn and granular cells of the dentate gyrus in the hippocampus as well as cerebral cortex and striatum. High levels in dorsal horn of spinal cord.
Cellular localization
- Cell membrane
- Lipid-anchor
- Postsynaptic density
- Synapse
- Cell projection
- Axon
- Membrane
- Perikaryon
- Concentrated in soma and postsynaptic density of a subset of neurons (PubMed:11095503).
Alternative names
Dlgh2, Dlg2, Disks large homolog 2, Channel-associated protein of synapse-110, Postsynaptic density protein PSD-93, Chapsyn-110