DLGAP5
Developmental stage
Elevated levels of expression detected in the G2/M phase of synchronized cultures of HeLa cells.
Function
Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.
Post-translational modifications
Ubiquitinated, leading to its degradation.
Decreased phosphorylation levels are associated with the differentiation of intestinal epithelial cells.
Sequence Similarities
Belongs to the SAPAP family.
Tissue Specificity
Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta.
Cellular localization
- Nucleus
- Cytoplasm
- Cytoplasm
- Cytoskeleton
- Spindle
- Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.
Alternative names
DLG7, KIAA0008, DLGAP5, Disks large-associated protein 5, DAP-5, Discs large homolog 7, Disks large-associated protein DLG7, Hepatoma up-regulated protein, HURP