Dll4
Developmental stage
At 14.5, expressed within the retina outer neuroblastic layer.
Function
Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (By similarity). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (PubMed:22323600). During spinal cord neurogenesis, inhibits V2a interneuron fate (By similarity).
Tissue Specificity
Expressed in vascular endothelium. Expressed in retina at least during embryogenesis.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
Alternative names
Delta-like protein 4, Drosophila Delta homolog 4, Delta4, Dll4