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DNAJA1

OverviewProducts

Function

Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202).

Tissue specificity

Ubiquitous. Isoform 2 is highly expressed in testis and lung, but detected at low levels in thymus, prostate, colon and liver.

Cellular localization

  • Membrane
  • Lipid-anchor
  • Cytoplasm
  • Microsome
  • Nucleus
  • Cytoplasm
  • Perinuclear region
  • Mitochondrion
  • Primarily associated with microsomes. A minor proportion is associated with mitochondria (By similarity). Primarily cytoplasmic. A minor proportion is associated with nuclei.

Alternative names

  • DnaJ homolog subfamily A member 1
  • DnaJ protein homolog 2
  • HSDJ
  • Heat shock 40 kDa protein 4
  • Heat shock protein J2
  • Human DnaJ protein 2
  • HSJ-2
  • hDj-2
  • HDJ2
  • HSPF4
  • DNAJ2
  • HSJ2
  • DNAJA1

Database links

Target type

Proteins

Molecular weight

44868Da