DNAJA3
Domain
Modulation of apoptosis, i.e. proapoptotic activity of isoform 1 and antiapoptotic activity of isoform 2, is J domain-dependent.
Function
Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.
Post-translational modifications
Tyrosine phosphorylated.
Tissue Specificity
Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes.
Cellular localization
- Mitochondrion matrix
- Cytoplasm
- Cytosol
- Postsynaptic cell membrane
- Peripheral membrane protein
- Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK.
Alternative names
HCA57, TID1, DNAJA3, DnaJ protein Tid-1, Hepatocellular carcinoma-associated antigen 57, Tumorous imaginal discs protein Tid56 homolog, hTid-1