DNAJB1

Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).

• Cytoplasm
• Nucleus
• Nucleus
• Nucleolus
• Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock.

DNAJ1, HDJ1, HSPF1, DNAJB1, DnaJ homolog subfamily B member 1, DnaJ protein homolog 1, Heat shock 40 kDa protein 1, Human DnaJ protein 1, HSP40, Heat shock protein 40, hDj-1

• entrezGene:3337
• omim:604572
• swissprot:P25685

Proteins

Oncology

38044Da